Assay Detail
Binding
CHEMBL807133
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards serotonin transporter in rat striatum using [3H]citalopram as radioligand
10
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
High affinity hydroxypiperidine analogues of 4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidine for the dopamine transporter: stereospecific interactions in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.79 | 6.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | 3.0 | 1 | 6.88 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.13 |
| CHEMBL20432 | — | — | 1 | 5.96 |
| CHEMBL21115 | — | — | 2 | 5.74 |
| CHEMBL20648 | — | — | 1 | 5.72 |
| CHEMBL20127 | — | — | 1 | 5.48 |
| CHEMBL21213 | — | — | 1 | 5.44 |
| CHEMBL20710 | — | — | 1 | 5.11 |
| CHEMBL20362 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL370805 | COCAINE | IC50 | = | 737.0 | nM | 6.13 |
| CHEMBL20432 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL21115 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL20648 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL21115 | — | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL20127 | — | IC50 | = | 3310.0 | nM | 5.48 |
| CHEMBL21213 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL20710 | — | IC50 | = | 7750.0 | nM | 5.11 |
| CHEMBL20362 | — | IC50 | = | 178000.0 | nM | - |