Assay Detail
Binding
CHEMBL807135
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Binding potency for Serotonin transporter using [3H]- paroxetine
11
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
3 alpha-(4'-substituted phenyl)tropane-2 beta-carboxylic acid methyl esters: novel ligands with high affinity and selectivity at the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.29 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14391 | — | — | 2 | 8.38 |
| CHEMBL306208 | — | — | 2 | 7.35 |
| CHEMBL82027 | — | — | 2 | 6.62 |
| CHEMBL2079586 | — | — | 2 | 6.09 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 5.98 |
| CHEMBL1790051 | — | — | 2 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14391 | — | IC50 | = | 4.21 | nM | 8.38 |
| CHEMBL306208 | — | IC50 | = | 44.5 | nM | 7.35 |
| CHEMBL14391 | — | IC50 | = | 64.9 | nM | 7.19 |
| CHEMBL82027 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL2079586 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL306208 | — | IC50 | = | 998.0 | nM | 6.00 |
| CHEMBL370805 | COCAINE | IC50 | = | 1045.0 | nM | 5.98 |
| CHEMBL1790051 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL82027 | — | IC50 | = | 4250.0 | nM | 5.37 |
| CHEMBL2079586 | — | IC50 | = | 5060.0 | nM | 5.30 |
| CHEMBL1790051 | — | IC50 | = | 5700.0 | nM | 5.24 |