Assay Detail
Functional
CHEMBL807812
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Concentration for 50% reduction in THp-1 cell numbers, expressed as IC50
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Peripheral substituents of di(pyridiumyl)porphyrins affected on their interactions with DNA.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.46 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432374 | — | — | 1 | 9.96 |
| CHEMBL421734 | — | — | 1 | 7.92 |
| CHEMBL84664 | — | — | 1 | 7.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432374 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL421734 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL84664 | — | IC50 | = | 32.0 | nM | 7.50 |