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Assay Detail

CHEMBL807817

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory activity evaluated against human THP-1 cell line in cellular assay
ChEMBL ↗
63
Total Activities
63
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type THP-1
Confidence 1 — Organism
Curated By Expert

Target

THP-1 (CHEMBL614245) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke.
Linton SD, Aja T, Allegrini PR, Deckwerth TL, Diaz JL, Hengerer B, Herrmann J, Jahangiri KG, Kallen J, Karanewsky DS, Meduna SP, Nalley K, Robinson ED, Roggo S, Rovelli G, Sauter A, Sayers RO, Schmitz A, Smidt R, Ternansky RJ, Tomaselli KJ, Ullman BR, Wiessner C, Wu JC.
Bioorg Med Chem Lett (2004) 14 : 2685 -2691
PubMed 15109679 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 63 6.04 7.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL327207 — — 1 7.16
CHEMBL316450 — — 1 7.10
CHEMBL88795 — — 1 7.05
CHEMBL92848 — — 1 6.80
CHEMBL91442 — — 1 6.80
CHEMBL92355 — — 1 6.77
CHEMBL328066 — — 1 6.75
CHEMBL88719 — — 1 6.66
CHEMBL91305 — — 1 6.60
CHEMBL88358 — — 1 6.57
CHEMBL88728 — — 1 6.57
CHEMBL91236 — — 1 6.55
CHEMBL330110 — — 1 6.43
CHEMBL315868 — — 1 6.42
CHEMBL90589 — — 1 6.40
CHEMBL91406 — — 1 6.39
CHEMBL91825 — — 1 6.33
CHEMBL90914 — — 1 6.32
CHEMBL327821 — — 1 6.27
CHEMBL315954 — — 1 6.24
CHEMBL327211 — — 1 6.24
CHEMBL313158 — — 1 6.21
CHEMBL93177 — — 1 6.20
CHEMBL91281 — — 1 6.19
CHEMBL91032 — — 1 6.18
CHEMBL90516 — — 1 6.17
CHEMBL92317 — — 1 6.16
CHEMBL91279 — — 1 6.14
CHEMBL92029 — — 1 6.11
CHEMBL90185 — — 1 6.09

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL327207 — IC50 = 70.0 nM 7.16
CHEMBL316450 — IC50 = 80.0 nM 7.10
CHEMBL88795 — IC50 = 90.0 nM 7.05
CHEMBL92848 — IC50 = 160.0 nM 6.80
CHEMBL91442 — IC50 = 160.0 nM 6.80
CHEMBL92355 — IC50 = 170.0 nM 6.77
CHEMBL328066 — IC50 = 180.0 nM 6.75
CHEMBL88719 — IC50 = 220.0 nM 6.66
CHEMBL91305 — IC50 = 250.0 nM 6.60
CHEMBL88358 — IC50 = 270.0 nM 6.57
CHEMBL88728 — IC50 = 270.0 nM 6.57
CHEMBL91236 — IC50 = 280.0 nM 6.55
CHEMBL330110 — IC50 = 370.0 nM 6.43
CHEMBL315868 — IC50 = 380.0 nM 6.42
CHEMBL90589 — IC50 = 400.0 nM 6.40
CHEMBL91406 — IC50 = 410.0 nM 6.39
CHEMBL91825 — IC50 = 470.0 nM 6.33
CHEMBL90914 — IC50 = 480.0 nM 6.32
CHEMBL327821 — IC50 = 540.0 nM 6.27
CHEMBL315954 — IC50 = 570.0 nM 6.24
CHEMBL327211 — IC50 = 570.0 nM 6.24
CHEMBL313158 — IC50 = 610.0 nM 6.21
CHEMBL93177 — IC50 = 630.0 nM 6.20
CHEMBL91281 — IC50 = 650.0 nM 6.19
CHEMBL91032 — IC50 = 660.0 nM 6.18
CHEMBL90516 — IC50 = 680.0 nM 6.17
CHEMBL92317 — IC50 = 700.0 nM 6.16
CHEMBL91279 — IC50 = 720.0 nM 6.14
CHEMBL92029 — IC50 = 780.0 nM 6.11
CHEMBL90185 — IC50 = 820.0 nM 6.09
CHEMBL91181 — IC50 = 840.0 nM 6.08
CHEMBL313390 — IC50 = 930.0 nM 6.03
CHEMBL316289 — IC50 = 1050.0 nM 5.98
CHEMBL88786 — IC50 = 1100.0 nM 5.96
CHEMBL313159 — IC50 = 1120.0 nM 5.95
CHEMBL314733 — IC50 = 1210.0 nM 5.92
CHEMBL328988 — IC50 = 1230.0 nM 5.91
CHEMBL329787 — IC50 = 1260.0 nM 5.90
CHEMBL94069 — IC50 = 1280.0 nM 5.89
CHEMBL1160621 — IC50 = 1440.0 nM 5.84
CHEMBL1160622 — IC50 = 1430.0 nM 5.84
CHEMBL88517 — IC50 = 1440.0 nM 5.84
CHEMBL91303 — IC50 = 1490.0 nM 5.83
CHEMBL314096 — IC50 = 1500.0 nM 5.82
CHEMBL90293 — IC50 = 1510.0 nM 5.82
CHEMBL327683 — IC50 = 1790.0 nM 5.75
CHEMBL327464 — IC50 = 1770.0 nM 5.75
CHEMBL327458 — IC50 = 1850.0 nM 5.73
CHEMBL93960 — IC50 = 1850.0 nM 5.73
CHEMBL328505 — IC50 = 1930.0 nM 5.71