Assay Detail
Functional
CHEMBL807831
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit production of arachidonic acid from THP-1 cells stimulated with A-23187
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Pyrrolidine inhibitors of human cytosolic phospholipase A2. Part 2: synthesis of potent and crystallized 4-triphenylmethylthio derivative 'pyrrophenone'.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.57 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL385730 | — | — | 1 | 7.62 |
| CHEMBL268905 | — | — | 1 | 6.17 |
| CHEMBL15594 | ARACHIDONIC ACID | -1.0 | 1 | 4.40 |
| CHEMBL281211 | ARACHIDONYL TRIFLUOROMETHYLKETONE | — | 1 | 4.07 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL385730 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL268905 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL15594 | ARACHIDONIC ACID | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL281211 | ARACHIDONYL TRIFLUOROMETHYLKETONE | IC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL6 | INDOMETHACIN | IC50 | > | 10000.0 | nM | - |