Assay Detail
Functional
CHEMBL807835
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Effect of pyrrolidine derivatives on production of eicosanoids from THP-1 cells stimulated with A-23187 using cellular assay on PGE-2, LTC-4
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Pyrrolidine inhibitors of human cytosolic phospholipase A(2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.24 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441326 | — | — | 1 | 7.89 |
| CHEMBL9277 | — | — | 1 | 6.58 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441326 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL9277 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL6 | INDOMETHACIN | IC50 | > | 10000.0 | nM | - |