Assay Detail
Binding
CHEMBL808121
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Inhibition of [3H]paroxetine binding at serotonin transporter was determined
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
2002 Medicinal Chemistry Division Award address: monoamine transporters and opioid receptors. Targets for addiction therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 7.88 | 10.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51154 | — | — | 1 | 10.26 |
| CHEMBL297507 | — | — | 1 | 10.20 |
| CHEMBL2373961 | — | — | 1 | 9.55 |
| CHEMBL300226 | — | — | 1 | 9.42 |
| CHEMBL2310926 | — | — | 1 | 9.19 |
| CHEMBL301562 | — | — | 1 | 9.13 |
| CHEMBL50858 | — | — | 1 | 9.02 |
| CHEMBL2310929 | — | — | 1 | 9.02 |
| CHEMBL50157 | — | — | 1 | 8.59 |
| CHEMBL300220 | — | — | 1 | 8.44 |
| CHEMBL610897 | — | — | 1 | 8.39 |
| CHEMBL2373962 | — | — | 1 | 7.66 |
| CHEMBL301938 | — | — | 1 | 7.62 |
| CHEMBL51617 | — | — | 1 | 7.34 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 7.02 |
| CHEMBL52324 | — | — | 1 | 7.01 |
| CHEMBL1643896 | — | — | 1 | 6.80 |
| CHEMBL1790051 | — | — | 1 | 6.75 |
| CHEMBL14144 | — | — | 1 | 6.67 |
| CHEMBL298580 | — | — | 1 | 6.66 |
| CHEMBL432878 | — | — | 1 | 6.28 |
| CHEMBL298703 | — | — | 1 | 6.26 |
| CHEMBL51771 | — | — | 1 | 6.00 |
| CHEMBL51355 | — | — | 1 | 5.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51154 | — | Ki | = | 0.055 | nM | 10.26 |
| CHEMBL297507 | — | Ki | = | 0.063 | nM | 10.20 |
| CHEMBL2373961 | — | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL300226 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL2310926 | — | Ki | = | 0.65 | nM | 9.19 |
| CHEMBL301562 | — | Ki | = | 0.74 | nM | 9.13 |
| CHEMBL50858 | — | Ki | = | 0.95 | nM | 9.02 |
| CHEMBL2310929 | — | Ki | = | 0.96 | nM | 9.02 |
| CHEMBL50157 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL300220 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL610897 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL2373962 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL301938 | — | Ki | = | 23.8 | nM | 7.62 |
| CHEMBL51617 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL370805 | COCAINE | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL52324 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL1643896 | — | Ki | = | 157.0 | nM | 6.80 |
| CHEMBL1790051 | — | Ki | = | 178.0 | nM | 6.75 |
| CHEMBL14144 | — | Ki | = | 214.0 | nM | 6.67 |
| CHEMBL298580 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL432878 | — | Ki | = | 522.0 | nM | 6.28 |
| CHEMBL298703 | — | Ki | = | 554.0 | nM | 6.26 |
| CHEMBL51771 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL51355 | — | Ki | = | 1127.0 | nM | 5.95 |