Assay Detail
Binding
CHEMBL808122
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Ratio of Ki value towards Serotonin transporter to that of dopamine transporter
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Cocaine and 3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid ester and amide analogues. New high-affinity and selective compounds for the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.91 | 7.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127546 | — | — | 1 | 7.90 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.95 |
| CHEMBL1790051 | — | — | 1 | 6.76 |
| CHEMBL321806 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127546 | — | Ki | = | 12.54 | nM | 7.90 |
| CHEMBL370805 | COCAINE | Ki | = | 112.11 | nM | 6.95 |
| CHEMBL1790051 | — | Ki | = | 172.79 | nM | 6.76 |
| CHEMBL321806 | — | Ki | = | 917.11 | nM | 6.04 |