Assay Detail
Binding
CHEMBL808124
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Tested for the ability to displace [3H]- paroxetine binding in rat frontal cortex membrane against Serotonin transporter
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Frontal cortex |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis of iodinated 3beta-aryltropanes with selective binding to either the dopamine or serotonin transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 8.50 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL355259 | — | — | 1 | 9.89 |
| CHEMBL423275 | — | — | 1 | 9.24 |
| CHEMBL352913 | — | — | 1 | 9.21 |
| CHEMBL169117 | — | — | 1 | 8.97 |
| CHEMBL168455 | — | — | 1 | 8.94 |
| CHEMBL352698 | — | — | 1 | 8.73 |
| CHEMBL354725 | — | — | 1 | 8.61 |
| CHEMBL169361 | — | — | 1 | 8.55 |
| CHEMBL355734 | — | — | 1 | 8.14 |
| CHEMBL355650 | — | — | 1 | 8.04 |
| CHEMBL355733 | — | — | 1 | 7.88 |
| CHEMBL171565 | — | — | 1 | 7.80 |
| CHEMBL168305 | — | — | 1 | 7.71 |
| CHEMBL169320 | — | — | 1 | 7.29 |
| CHEMBL2112943 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL355259 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL423275 | — | Ki | = | 0.57 | nM | 9.24 |
| CHEMBL352913 | — | Ki | = | 0.62 | nM | 9.21 |
| CHEMBL169117 | — | Ki | = | 1.08 | nM | 8.97 |
| CHEMBL168455 | — | Ki | = | 1.14 | nM | 8.94 |
| CHEMBL352698 | — | Ki | = | 1.88 | nM | 8.73 |
| CHEMBL354725 | — | Ki | = | 2.44 | nM | 8.61 |
| CHEMBL169361 | — | Ki | = | 2.82 | nM | 8.55 |
| CHEMBL355734 | — | Ki | = | 7.26 | nM | 8.14 |
| CHEMBL355650 | — | Ki | = | 9.07 | nM | 8.04 |
| CHEMBL355733 | — | Ki | = | 13.1 | nM | 7.88 |
| CHEMBL171565 | — | Ki | = | 15.7 | nM | 7.80 |
| CHEMBL168305 | — | Ki | = | 19.7 | nM | 7.71 |
| CHEMBL169320 | — | Ki | = | 50.8 | nM | 7.29 |
| CHEMBL2112943 | — | Ki | > | 1100.0 | nM | - |