Assay Detail
Binding
CHEMBL808125
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Tested for the binding affinity towards Serotonin transporter in rat midbrain tissue by displacing [3H]paroxetine radioligand
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Midbrain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and transporter binding properties of 3beta-[4'-(phenylalkyl, -phenylalkenyl, and -phenylalkynyl)phenyl]tropane-2beta-carboxylic acid methyl esters: evidence of a remote phenyl binding domain on the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 7.86 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2310867 | — | — | 1 | 10.15 |
| CHEMBL3350431 | — | — | 1 | 9.40 |
| CHEMBL2310868 | — | — | 1 | 9.07 |
| CHEMBL2310874 | — | — | 1 | 8.98 |
| CHEMBL2310884 | — | — | 1 | 8.98 |
| CHEMBL2310871 | — | — | 1 | 8.92 |
| CHEMBL2310869 | — | — | 1 | 8.85 |
| CHEMBL50157 | — | — | 1 | 8.59 |
| CHEMBL2310872 | — | — | 1 | 8.37 |
| CHEMBL2310866 | — | — | 1 | 8.19 |
| CHEMBL2310876 | — | — | 1 | 8.06 |
| CHEMBL2310877 | — | — | 1 | 7.67 |
| CHEMBL2373962 | — | — | 1 | 7.66 |
| CHEMBL2310883 | — | — | 1 | 7.52 |
| CHEMBL84680 | — | — | 1 | 7.50 |
| CHEMBL2310881 | — | — | 1 | 7.15 |
| CHEMBL2310870 | — | — | 1 | 7.12 |
| CHEMBL2310878 | — | — | 1 | 6.95 |
| CHEMBL2310875 | — | — | 1 | 6.91 |
| CHEMBL1790051 | — | — | 1 | 6.75 |
| CHEMBL2310873 | — | — | 1 | 6.70 |
| CHEMBL2310879 | — | — | 1 | 6.61 |
| CHEMBL2310865 | — | — | 1 | 6.36 |
| CHEMBL2310880 | — | — | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2310867 | — | Ki | = | 0.07 | nM | 10.15 |
| CHEMBL3350431 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL2310868 | — | Ki | = | 0.86 | nM | 9.07 |
| CHEMBL2310874 | — | Ki | = | 1.05 | nM | 8.98 |
| CHEMBL2310884 | — | Ki | = | 1.04 | nM | 8.98 |
| CHEMBL2310871 | — | Ki | = | 1.19 | nM | 8.92 |
| CHEMBL2310869 | — | Ki | = | 1.43 | nM | 8.85 |
| CHEMBL50157 | — | Ki | = | 2.58 | nM | 8.59 |
| CHEMBL2310872 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL2310866 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL2310876 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL2310877 | — | Ki | = | 21.3 | nM | 7.67 |
| CHEMBL2373962 | — | Ki | = | 21.8 | nM | 7.66 |
| CHEMBL2310883 | — | Ki | = | 30.5 | nM | 7.52 |
| CHEMBL84680 | — | Ki | = | 31.4 | nM | 7.50 |
| CHEMBL2310881 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL2310870 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL2310878 | — | Ki | = | 113.0 | nM | 6.95 |
| CHEMBL2310875 | — | Ki | = | 122.0 | nM | 6.91 |
| CHEMBL1790051 | — | Ki | = | 178.0 | nM | 6.75 |
| CHEMBL2310873 | — | Ki | = | 198.0 | nM | 6.70 |
| CHEMBL2310879 | — | Ki | = | 246.0 | nM | 6.61 |
| CHEMBL2310865 | — | Ki | = | 439.0 | nM | 6.36 |
| CHEMBL2310880 | — | Ki | = | 658.0 | nM | 6.18 |