Assay Detail
Binding
CHEMBL808127
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against Serotonin transporter in male Sprague-Dawley rats using [3H]paroxetine ligand
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structure-activity relationships at the monoamine transporters and sigma receptors for a novel series of 9-[3-(cis-3, 5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole) analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.12 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2112783 | — | — | 1 | 7.35 |
| CHEMBL2112787 | — | — | 1 | 6.66 |
| CHEMBL2112760 | — | — | 1 | 6.43 |
| CHEMBL275707 | RIMCAZOLE | 2.0 | 1 | 6.08 |
| CHEMBL2112789 | — | — | 1 | 5.95 |
| CHEMBL2112788 | — | — | 1 | 5.93 |
| CHEMBL2112791 | — | — | 1 | 5.68 |
| CHEMBL2112784 | — | — | 1 | 4.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2112783 | — | Ki | = | 44.5 | nM | 7.35 |
| CHEMBL2112787 | — | Ki | = | 219.0 | nM | 6.66 |
| CHEMBL2112760 | — | Ki | = | 373.0 | nM | 6.43 |
| CHEMBL275707 | RIMCAZOLE | Ki | = | 825.0 | nM | 6.08 |
| CHEMBL2112789 | — | Ki | = | 1130.0 | nM | 5.95 |
| CHEMBL2112788 | — | Ki | = | 1170.0 | nM | 5.93 |
| CHEMBL2112791 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL2112784 | — | Ki | = | 13100.0 | nM | 4.88 |