Assay Detail
Binding
CHEMBL808138
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against Serotonin transporter in male Sprague-Dawley rats using [3H]paroxetine ligand
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structure-activity relationships at the monoamine transporters and sigma receptors for a novel series of 9-[3-(cis-3, 5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole) analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.48 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | 3.0 | 1 | 7.62 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.76 |
| CHEMBL314726 | — | — | 1 | 5.79 |
| CHEMBL2112790 | — | — | 1 | 5.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | Ki | = | 24.1 | nM | 7.62 |
| CHEMBL370805 | COCAINE | Ki | = | 172.0 | nM | 6.76 |
| CHEMBL314726 | — | Ki | = | 1610.0 | nM | 5.79 |
| CHEMBL2112790 | — | Ki | = | 1850.0 | nM | 5.73 |