Assay Detail
Binding
CHEMBL808143
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro ability of compound to inhibit 5-HT re-uptake of radiolabeled [3H]-tritium transmitter into synaptosome
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Bicyclo[2.2.1]heptanes as novel triple re-uptake inhibitors for the treatment of depression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.40 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL111128 | — | — | 1 | 8.05 |
| CHEMBL326466 | — | — | 1 | 8.05 |
| CHEMBL109571 | — | — | 1 | 8.00 |
| CHEMBL109517 | — | — | 1 | 7.70 |
| CHEMBL331799 | — | — | 1 | 7.30 |
| CHEMBL323447 | — | — | 1 | 7.03 |
| CHEMBL322067 | — | — | 1 | 6.57 |
| CHEMBL113136 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL111128 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL326466 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL109571 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL109517 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL331799 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL323447 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL322067 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL113136 | — | IC50 | = | 303.0 | nM | 6.52 |