Assay Detail
Binding
CHEMBL808179
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]- N-allylnormetazocine ([3H]NANM) binding to sigma receptor
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL3602) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Phencyclidine-like effects of tetrahydroisoquinolines and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 5.54 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL21326 | — | — | 1 | 7.30 |
| CHEMBL279676 | TENOCYCLIDINE | 2.0 | 1 | 6.62 |
| CHEMBL21640 | — | — | 1 | 6.37 |
| CHEMBL275528 | PHENCYCLIDINE | 2.0 | 1 | 6.28 |
| CHEMBL21805 | — | — | 1 | 5.89 |
| CHEMBL21464 | — | — | 1 | 5.89 |
| CHEMBL283744 | — | — | 1 | 5.80 |
| CHEMBL284237 | DIZOCILPINE | 2.0 | 1 | 5.77 |
| CHEMBL21277 | — | — | 1 | 5.75 |
| CHEMBL442106 | — | — | 1 | 5.75 |
| CHEMBL21465 | — | — | 1 | 5.70 |
| CHEMBL21484 | — | — | 1 | 5.66 |
| CHEMBL282475 | — | — | 1 | 5.60 |
| CHEMBL277493 | — | — | 1 | 5.58 |
| CHEMBL21342 | — | — | 1 | 5.58 |
| CHEMBL283105 | — | — | 1 | 5.57 |
| CHEMBL22053 | — | — | 1 | 5.57 |
| CHEMBL278781 | — | — | 1 | 5.54 |
| CHEMBL22005 | — | — | 1 | 5.51 |
| CHEMBL22078 | — | — | 1 | 5.50 |
| CHEMBL21920 | — | — | 1 | 5.47 |
| CHEMBL21830 | — | — | 1 | 5.42 |
| CHEMBL22133 | — | — | 1 | 5.42 |
| CHEMBL283130 | — | — | 1 | 5.38 |
| CHEMBL21273 | — | — | 1 | 5.30 |
| CHEMBL418745 | — | — | 1 | 5.30 |
| CHEMBL21323 | — | — | 1 | 5.27 |
| CHEMBL21969 | — | — | 1 | 5.25 |
| CHEMBL281568 | — | — | 1 | 5.20 |
| CHEMBL283377 | — | — | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL21326 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL279676 | TENOCYCLIDINE | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL21640 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL275528 | PHENCYCLIDINE | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL21805 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL21464 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL283744 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL284237 | DIZOCILPINE | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL21277 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL442106 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL21465 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL21484 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL282475 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL277493 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL21342 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL283105 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL22053 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL278781 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL22005 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL22078 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL21920 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL21830 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL22133 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL283130 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL21273 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL418745 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL21323 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL21969 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL281568 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL283377 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL21272 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL279013 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL21633 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL21911 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL21477 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL22009 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL283104 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL21672 | — | IC50 | > | 30000.0 | nM | - |