Assay Detail
Binding
CHEMBL808183
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Inhibition of [3H]DTG binding to sigma receptor in rat hippocampus
9
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Hippocampus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL3602) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
New benzocycloalkylpiperazines, potent and selective 5-HT1A receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.66 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL366388 | — | — | 1 | 7.52 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 7.32 |
| CHEMBL354210 | — | — | 1 | 7.05 |
| CHEMBL368061 | — | — | 3 | 6.89 |
| CHEMBL177031 | — | — | 2 | 6.70 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL366388 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL49 | BUSPIRONE | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL354210 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL368061 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL368061 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL177031 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL368061 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL177031 | — | Ki | = | 1250.0 | nM | 5.90 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 5240.0 | nM | 5.28 |