Assay Detail
Binding
CHEMBL808187
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]NANM binding to sigma receptor obtained from tissue homogenate preparation of fresh whole rat brain minus cerebellum
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL3602) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Rigid phencyclidine analogues. Binding to the phencyclidine and sigma 1 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.67 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7393 | — | — | 1 | 7.89 |
| CHEMBL305881 | — | — | 1 | 7.36 |
| CHEMBL145722 | — | — | 1 | 6.50 |
| CHEMBL142600 | — | — | 1 | 6.48 |
| CHEMBL356757 | — | — | 1 | 6.44 |
| CHEMBL275528 | PHENCYCLIDINE | 2.0 | 1 | 6.28 |
| CHEMBL284237 | DIZOCILPINE | 2.0 | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7393 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL305881 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL145722 | — | IC50 | = | 319.0 | nM | 6.50 |
| CHEMBL142600 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL356757 | — | IC50 | = | 365.0 | nM | 6.44 |
| CHEMBL275528 | PHENCYCLIDINE | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL284237 | DIZOCILPINE | IC50 | = | 1700.0 | nM | 5.77 |