Assay Detail
Binding
CHEMBL808280
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity against Sigma opioid receptor type 2 using [3H]- DTG in rat liver membranes
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL287) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Asymmetric synthesis of 9-alkyl-2-benzyl-6,7-benzomorphans: characterization as novel sigma receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 6.40 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL560 | — | — | 1 | 7.44 |
| CHEMBL139900 | — | — | 1 | 6.94 |
| CHEMBL140618 | — | — | 1 | 6.88 |
| CHEMBL336235 | — | — | 1 | 6.88 |
| CHEMBL141070 | — | — | 1 | 6.83 |
| CHEMBL356486 | — | — | 1 | 6.72 |
| CHEMBL423548 | — | — | 1 | 6.43 |
| CHEMBL341874 | — | — | 1 | 6.32 |
| CHEMBL143050 | — | — | 1 | 6.31 |
| CHEMBL143585 | — | — | 1 | 6.23 |
| CHEMBL143486 | — | — | 1 | 6.22 |
| CHEMBL344813 | — | — | 1 | 6.12 |
| CHEMBL143660 | — | — | 1 | 6.11 |
| CHEMBL139774 | — | — | 1 | 6.07 |
| CHEMBL346665 | — | — | 1 | 6.07 |
| CHEMBL435046 | — | — | 1 | 6.03 |
| CHEMBL60542 | (+)-PENTAZOCINE | — | 1 | 5.81 |
| CHEMBL143103 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL560 | — | Ki | = | 36.5 | nM | 7.44 |
| CHEMBL139900 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL140618 | — | Ki | = | 131.0 | nM | 6.88 |
| CHEMBL336235 | — | Ki | = | 133.0 | nM | 6.88 |
| CHEMBL141070 | — | Ki | = | 149.0 | nM | 6.83 |
| CHEMBL356486 | — | Ki | = | 192.0 | nM | 6.72 |
| CHEMBL423548 | — | Ki | = | 371.0 | nM | 6.43 |
| CHEMBL341874 | — | Ki | = | 478.0 | nM | 6.32 |
| CHEMBL143050 | — | Ki | = | 487.0 | nM | 6.31 |
| CHEMBL143585 | — | Ki | = | 587.0 | nM | 6.23 |
| CHEMBL143486 | — | Ki | = | 607.0 | nM | 6.22 |
| CHEMBL344813 | — | Ki | = | 759.0 | nM | 6.12 |
| CHEMBL143660 | — | Ki | = | 785.0 | nM | 6.11 |
| CHEMBL139774 | — | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL346665 | — | Ki | = | 854.0 | nM | 6.07 |
| CHEMBL435046 | — | Ki | = | 944.0 | nM | 6.03 |
| CHEMBL60542 | (+)-PENTAZOCINE | Ki | = | 1540.0 | nM | 5.81 |
| CHEMBL143103 | — | Ki | = | 1710.0 | nM | 5.77 |