Assay Detail
Binding
CHEMBL808863
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards Serotonin transporter using [3H]paroxetine as radioligand
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structural determinants for high 5-HT(2A) receptor affinity of spiro[9,10-dihydroanthracene]-9,3(')-pyrrolidine (SpAMDA).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.37 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11 | IMIPRAMINE | 4.0 | 1 | 8.30 |
| CHEMBL307956 | — | — | 1 | 5.41 |
| CHEMBL516 | CYPROHEPTADINE | 4.0 | 1 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11 | IMIPRAMINE | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL307956 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL516 | CYPROHEPTADINE | Ki | = | 4100.0 | nM | 5.39 |