Assay Detail
Binding
CHEMBL808864
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Displacement of [3H]-citalopram from Serotonin transporter
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Bicyclo[2.2.1]heptanes as novel triple re-uptake inhibitors for the treatment of depression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 8.01 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL326466 | — | — | 1 | 8.64 |
| CHEMBL324269 | — | — | 1 | 8.59 |
| CHEMBL109571 | — | — | 1 | 8.55 |
| CHEMBL111128 | — | — | 1 | 8.44 |
| CHEMBL432022 | — | — | 1 | 8.36 |
| CHEMBL331799 | — | — | 1 | 8.31 |
| CHEMBL109517 | — | — | 1 | 8.24 |
| CHEMBL322348 | — | — | 1 | 7.92 |
| CHEMBL323678 | — | — | 1 | 7.60 |
| CHEMBL113136 | — | — | 1 | 7.60 |
| CHEMBL419385 | — | — | 1 | 7.33 |
| CHEMBL323447 | — | — | 1 | 7.28 |
| CHEMBL322067 | — | — | 1 | 7.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL326466 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL324269 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL109571 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL111128 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL432022 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL331799 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL109517 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL322348 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL323678 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL113136 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL419385 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL323447 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL322067 | — | Ki | = | 57.0 | nM | 7.24 |