Assay Detail
Binding
CHEMBL809042
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Binding effinity for sigma receptor using 2 nM of [3H]DTG as radioligand, in membranes from brain minus cerebellum
5
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL3602) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Substituted 3-phenylpiperidines: new centrally acting dopamine autoreceptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.76 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL110821 | — | — | 1 | 8.22 |
| CHEMBL90359 | — | — | 1 | 7.50 |
| CHEMBL276500 | — | — | 2 | 6.37 |
| CHEMBL107492 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL110821 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL90359 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL276500 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL276500 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL107492 | — | IC50 | = | 2200.0 | nM | 5.66 |