Assay Detail
Binding
CHEMBL809049
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity at Sigma opioid receptor type 2 on guinea pig brain membranes by [3H]DTG displacement in the presence of [3H]pentazocine.
4
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL287) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and SAR of 1-alkyl-2-phenylethylamine derivatives designed from N,N-dipropyl-4-methoxy-3-(2-phenylethoxy)phenylethylamine to discover sigma(1) ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.79 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL521582 | — | — | 1 | 7.07 |
| CHEMBL540331 | — | — | 2 | 6.72 |
| CHEMBL541091 | — | — | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL521582 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL540331 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL540331 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL541091 | — | IC50 | = | 210.0 | nM | 6.68 |