Assay Detail
Binding
CHEMBL809261
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Inhibition of [3H]5-HT reuptake at serotonin transporter in rat mid brain
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Thiophene derivatives: a new series of potent norepinephrine and serotonin reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.05 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58858 | — | — | 1 | 10.22 |
| CHEMBL58195 | — | — | 1 | 10.00 |
| CHEMBL366383 | — | — | 1 | 8.81 |
| CHEMBL119477 | — | — | 1 | 7.54 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.81 |
| CHEMBL173834 | — | — | 1 | 6.78 |
| CHEMBL369497 | — | — | 1 | 6.77 |
| CHEMBL117047 | — | — | 1 | 6.75 |
| CHEMBL174854 | — | — | 1 | 5.94 |
| CHEMBL367744 | — | — | 1 | 5.82 |
| CHEMBL331565 | — | — | 1 | 5.69 |
| CHEMBL366993 | — | — | 1 | 5.63 |
| CHEMBL175338 | — | — | 1 | 4.88 |
| CHEMBL173835 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58858 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL58195 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL366383 | — | Ki | = | 1.53 | nM | 8.81 |
| CHEMBL119477 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL370805 | COCAINE | Ki | = | 155.0 | nM | 6.81 |
| CHEMBL173834 | — | Ki | = | 168.0 | nM | 6.78 |
| CHEMBL369497 | — | Ki | = | 169.0 | nM | 6.77 |
| CHEMBL117047 | — | Ki | = | 179.0 | nM | 6.75 |
| CHEMBL174854 | — | Ki | = | 1150.0 | nM | 5.94 |
| CHEMBL367744 | — | Ki | = | 1530.0 | nM | 5.82 |
| CHEMBL331565 | — | Ki | = | 2046.0 | nM | 5.69 |
| CHEMBL366993 | — | Ki | = | 2360.0 | nM | 5.63 |
| CHEMBL175338 | — | Ki | = | 13300.0 | nM | 4.88 |
| CHEMBL173835 | — | Ki | ~ | 1000.0 | nM | - |