Assay Detail
Binding
CHEMBL809425
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]paroxetine binding to serotonin transport sites in rat frontal cortex membranes.
21
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Frontal cortex |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis of 2 beta-acyl-3 beta-aryl-8-azabicyclo[3.2.1]octanes and their binding affinities at dopamine and serotonin transport sites in rat striatum and frontal cortex.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 7.27 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL418190 | — | — | 3 | 9.92 |
| CHEMBL22930 | — | — | 1 | 8.97 |
| CHEMBL22518 | — | — | 1 | 8.37 |
| CHEMBL278572 | — | — | 1 | 7.68 |
| CHEMBL23672 | — | — | 1 | 7.59 |
| CHEMBL278122 | — | — | 1 | 7.45 |
| CHEMBL23142 | — | — | 3 | 7.13 |
| CHEMBL23974 | — | — | 1 | 7.11 |
| CHEMBL23141 | — | — | 1 | 6.91 |
| CHEMBL23655 | — | — | 1 | 6.20 |
| CHEMBL22665 | — | — | 1 | 6.07 |
| CHEMBL23875 | — | — | 1 | 6.00 |
| CHEMBL416007 | — | — | 1 | 5.87 |
| CHEMBL22377 | — | — | 1 | 5.75 |
| CHEMBL281413 | — | — | 1 | - |
| CHEMBL280382 | — | — | 1 | - |
| CHEMBL277200 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL418190 | — | Ki | = | 0.121 | nM | 9.92 |
| CHEMBL418190 | — | Ki | = | 0.394 | nM | 9.40 |
| CHEMBL22930 | — | Ki | = | 1.06 | nM | 8.97 |
| CHEMBL22518 | — | Ki | = | 4.31 | nM | 8.37 |
| CHEMBL278572 | — | Ki | = | 20.9 | nM | 7.68 |
| CHEMBL23672 | — | Ki | = | 25.6 | nM | 7.59 |
| CHEMBL278122 | — | Ki | = | 35.8 | nM | 7.45 |
| CHEMBL23142 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL23974 | — | Ki | = | 78.2 | nM | 7.11 |
| CHEMBL23141 | — | Ki | = | 122.0 | nM | 6.91 |
| CHEMBL23142 | — | Ki | = | 131.0 | nM | 6.88 |
| CHEMBL418190 | — | Ki | = | 484.0 | nM | 6.32 |
| CHEMBL23655 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL22665 | — | Ki | = | 857.0 | nM | 6.07 |
| CHEMBL23875 | — | Ki | = | 1005.0 | nM | 6.00 |
| CHEMBL416007 | — | Ki | = | 1364.0 | nM | 5.87 |
| CHEMBL22377 | — | Ki | = | 1771.0 | nM | 5.75 |
| CHEMBL281413 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL280382 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL23142 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL277200 | — | Ki | > | 10000.0 | nM | - |