Assay Detail
Binding
CHEMBL809432
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to displace [3H]citalopram radioligand, for the Serotonin transporter in rat brain
9
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Enantioselective synthesis of S-(+)-2beta-carboalkoxy-3alpha-[bis(4-fluorophenyl)methoxy]tropanes as novel probes for the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.50 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL21859 | — | — | 2 | 6.16 |
| CHEMBL281388 | — | — | 2 | 5.73 |
| CHEMBL283154 | — | — | 2 | 5.69 |
| CHEMBL317757 | DIFLUOROBENZTROPINE | — | 1 | 5.49 |
| CHEMBL428704 | — | — | 2 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL21859 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL21859 | — | Ki | = | 1750.0 | nM | 5.76 |
| CHEMBL281388 | — | Ki | = | 1850.0 | nM | 5.73 |
| CHEMBL283154 | — | Ki | = | 2040.0 | nM | 5.69 |
| CHEMBL317757 | DIFLUOROBENZTROPINE | Ki | = | 3260.0 | nM | 5.49 |
| CHEMBL283154 | — | Ki | = | 3320.0 | nM | 5.48 |
| CHEMBL281388 | — | Ki | = | 3740.0 | nM | 5.43 |
| CHEMBL428704 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL428704 | — | Ki | = | 13800.0 | nM | 4.86 |