Assay Detail
Binding
CHEMBL809435
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for the inhibition of serotonin [3H]SER reuptake into rat forebrain membranes
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Forebrain |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Discovery of substituted 3,4-diphenyl-thiazoles as a novel class of monoamine transporter inhibitors through 3-D pharmacophore search using a new pharmacophore model derived from mazindol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.36 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL297102 | — | — | 1 | 7.17 |
| CHEMBL120901 | — | — | 1 | 6.81 |
| CHEMBL48892 | — | — | 1 | 6.65 |
| CHEMBL296907 | — | — | 1 | 6.40 |
| CHEMBL50901 | — | — | 1 | 6.37 |
| CHEMBL301094 | — | — | 1 | 6.36 |
| CHEMBL52392 | — | — | 1 | 6.07 |
| CHEMBL49736 | — | — | 1 | 5.85 |
| CHEMBL51993 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL297102 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL120901 | — | Ki | = | 155.0 | nM | 6.81 |
| CHEMBL48892 | — | Ki | = | 225.0 | nM | 6.65 |
| CHEMBL296907 | — | Ki | = | 398.0 | nM | 6.40 |
| CHEMBL50901 | — | Ki | = | 424.0 | nM | 6.37 |
| CHEMBL301094 | — | Ki | = | 433.0 | nM | 6.36 |
| CHEMBL52392 | — | Ki | = | 843.0 | nM | 6.07 |
| CHEMBL49736 | — | Ki | = | 1410.0 | nM | 5.85 |
| CHEMBL51993 | — | Ki | = | 2617.0 | nM | 5.58 |