Assay Detail
Binding
CHEMBL809439
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In vitro binding affinity for serotonin reuptake sites in rat frontal cortex membranes by [3H]paroxetine displacement.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Frontal cortex |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
SLV310, a novel, potential antipsychotic, combining potent dopamine D2 receptor antagonism with serotonin reuptake inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 8.70 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL335844 | — | — | 1 | 9.40 |
| CHEMBL131495 | — | — | 1 | 9.22 |
| CHEMBL338270 | — | — | 1 | 9.10 |
| CHEMBL339098 | — | — | 1 | 9.10 |
| CHEMBL335259 | — | — | 1 | 9.00 |
| CHEMBL129852 | — | — | 1 | 9.00 |
| CHEMBL422618 | — | — | 1 | 8.89 |
| CHEMBL336771 | — | — | 1 | 8.89 |
| CHEMBL421902 | — | — | 1 | 8.70 |
| CHEMBL423706 | — | — | 1 | 8.70 |
| CHEMBL130261 | — | — | 1 | 8.70 |
| CHEMBL414433 | — | — | 1 | 8.60 |
| CHEMBL133524 | — | — | 1 | 8.60 |
| CHEMBL276520 | INDALPINE | 4.0 | 1 | 8.60 |
| CHEMBL340220 | — | — | 1 | 8.52 |
| CHEMBL27811 | — | — | 1 | 8.22 |
| CHEMBL129979 | — | — | 1 | 7.80 |
| CHEMBL334956 | — | — | 1 | 7.60 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL335844 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL131495 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL338270 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL339098 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL335259 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL129852 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL422618 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL336771 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL421902 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL423706 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL130261 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL414433 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL133524 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL276520 | INDALPINE | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL340220 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL27811 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL129979 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL334956 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL54 | HALOPERIDOL | Ki | > | 1000.0 | nM | - |