Assay Detail
Binding
CHEMBL809440
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity of compound for Serotonin transporter with [3H]- paroxetine as radioligand in corpus striatum tissue from rat forebrain
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Corpus striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
N-Phthalimidoalkyl derivatives of 2-carbomethoxy-3-(4-iodophenyl)tropane (-CIT): Brain monoamine transporter affinity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 9.42 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL423692 | — | — | 1 | 9.70 |
| CHEMBL114837 | — | — | 1 | 9.68 |
| CHEMBL432029 | — | — | 1 | 9.47 |
| CHEMBL14391 | — | — | 1 | 9.36 |
| CHEMBL2112550 | — | — | 1 | 9.23 |
| CHEMBL114547 | — | — | 1 | 9.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL423692 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL114837 | — | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL432029 | — | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL14391 | — | Ki | = | 0.44 | nM | 9.36 |
| CHEMBL2112550 | — | Ki | = | 0.59 | nM | 9.23 |
| CHEMBL114547 | — | Ki | = | 0.84 | nM | 9.08 |