Assay Detail
Binding
CHEMBL809444
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Inhibition of 0.2 nM [3H]paroxetine binding to Serotonin transporter
13
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
3alpha-(4-Substituted phenyl)nortropane-2beta-carboxylic acid methyl esters show selective binding at the norepinephrine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.64 | 9.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL81525 | — | — | 2 | 9.42 |
| CHEMBL306208 | — | — | 2 | 8.40 |
| CHEMBL80515 | — | — | 2 | 8.21 |
| CHEMBL80262 | — | — | 2 | 7.92 |
| CHEMBL82027 | — | — | 2 | 7.66 |
| CHEMBL2079586 | — | — | 2 | 7.16 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 7.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL81525 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL306208 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL81525 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL80515 | — | Ki | = | 6.24 | nM | 8.21 |
| CHEMBL80515 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL80262 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL82027 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL80262 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL2079586 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL306208 | — | Ki | = | 91.0 | nM | 7.04 |
| CHEMBL370805 | COCAINE | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL82027 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL2079586 | — | Ki | = | 460.0 | nM | 6.34 |