Assay Detail
Binding
CHEMBL809529
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity at Sigma receptor type 2 on rat liver membranes receptor by [3H]DTG displacement.
21
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL3602) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and sigma binding properties of 2'-substituted 5,9 alpha-dimethyl-6,7-benzomorphans.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 6.49 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL560 | — | — | 1 | 7.44 |
| CHEMBL101300 | — | — | 2 | 7.37 |
| CHEMBL103157 | — | — | 2 | 7.29 |
| CHEMBL103156 | — | — | 1 | 7.25 |
| CHEMBL318877 | — | — | 2 | 6.72 |
| CHEMBL101607 | — | — | 2 | 6.64 |
| CHEMBL103816 | — | — | 1 | 6.59 |
| CHEMBL330601 | — | — | 1 | 6.53 |
| CHEMBL276078 | — | — | 2 | 6.42 |
| CHEMBL99854 | — | — | 1 | 6.30 |
| CHEMBL103319 | — | — | 1 | 6.16 |
| CHEMBL102406 | — | — | 1 | 6.08 |
| CHEMBL60542 | (+)-PENTAZOCINE | — | 1 | 5.81 |
| CHEMBL317354 | — | — | 1 | 5.72 |
| CHEMBL100789 | — | — | 1 | 5.69 |
| CHEMBL274099 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL560 | — | Ki | = | 36.5 | nM | 7.44 |
| CHEMBL101300 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL103157 | — | Ki | = | 51.8 | nM | 7.29 |
| CHEMBL103156 | — | Ki | = | 56.4 | nM | 7.25 |
| CHEMBL103157 | — | Ki | = | 154.0 | nM | 6.81 |
| CHEMBL318877 | — | Ki | = | 192.0 | nM | 6.72 |
| CHEMBL101607 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL103816 | — | Ki | = | 258.0 | nM | 6.59 |
| CHEMBL101300 | — | Ki | = | 264.0 | nM | 6.58 |
| CHEMBL330601 | — | Ki | = | 295.0 | nM | 6.53 |
| CHEMBL276078 | — | Ki | = | 381.0 | nM | 6.42 |
| CHEMBL276078 | — | Ki | = | 429.0 | nM | 6.37 |
| CHEMBL101607 | — | Ki | = | 487.0 | nM | 6.31 |
| CHEMBL99854 | — | Ki | = | 501.0 | nM | 6.30 |
| CHEMBL103319 | — | Ki | = | 691.0 | nM | 6.16 |
| CHEMBL102406 | — | Ki | = | 832.0 | nM | 6.08 |
| CHEMBL60542 | (+)-PENTAZOCINE | Ki | = | 1540.0 | nM | 5.81 |
| CHEMBL318877 | — | Ki | = | 1710.0 | nM | 5.77 |
| CHEMBL317354 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL100789 | — | Ki | = | 2037.0 | nM | 5.69 |
| CHEMBL274099 | — | Ki | > | 10000.0 | nM | - |