Assay Detail
Binding
CHEMBL809800
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity for Serotonin transporter by displacing [3H]paroxetine from rat forebrain
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and monoamine transporter affinity of 2beta-carbomethoxy-3beta-(2''-, 3''- or 4''-substituted) biphenyltropanes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.70 | 9.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL311347 | — | — | 1 | 9.34 |
| CHEMBL301174 | — | — | 1 | 9.10 |
| CHEMBL51896 | — | — | 1 | 8.86 |
| CHEMBL51454 | — | — | 1 | 8.72 |
| CHEMBL300511 | — | — | 1 | 7.53 |
| CHEMBL296394 | — | — | 1 | 7.50 |
| CHEMBL52334 | — | — | 1 | 7.38 |
| CHEMBL50674 | — | — | 1 | 7.17 |
| CHEMBL299635 | — | — | 1 | 7.10 |
| CHEMBL50997 | — | — | 1 | 6.75 |
| CHEMBL50886 | — | — | 1 | 5.30 |
| CHEMBL50675 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL311347 | — | Ki | = | 0.46 | nM | 9.34 |
| CHEMBL301174 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL51896 | — | Ki | = | 1.39 | nM | 8.86 |
| CHEMBL51454 | — | Ki | = | 1.89 | nM | 8.72 |
| CHEMBL300511 | — | Ki | = | 29.7 | nM | 7.53 |
| CHEMBL296394 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL52334 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL50674 | — | Ki | = | 67.3 | nM | 7.17 |
| CHEMBL299635 | — | Ki | = | 79.5 | nM | 7.10 |
| CHEMBL50997 | — | Ki | = | 179.0 | nM | 6.75 |
| CHEMBL50886 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL50675 | — | Ki | > | 3000.0 | nM | - |