Assay Detail
Binding
CHEMBL809862
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against Sigma opioid receptor type 2 in rat liver membranes using [3H]DTG (DuPont-NEN) as radioligand in the presence of (+)-pentazocine (100 nM)
9
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL3602) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Hydroxylated decahydroquinolines as ligands for the vesicular acetylcholine transporter: synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.93 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL316520 | — | — | 3 | 7.60 |
| CHEMBL20730 | VESAMICOL | — | 1 | 7.47 |
| CHEMBL97524 | — | — | 2 | 7.39 |
| CHEMBL95857 | — | — | 1 | 6.90 |
| CHEMBL50880 | — | — | 1 | 6.72 |
| CHEMBL95701 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL316520 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL20730 | VESAMICOL | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL97524 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL95857 | — | Ki | = | 127.0 | nM | 6.90 |
| CHEMBL50880 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL97524 | — | Ki | = | 233.0 | nM | 6.63 |
| CHEMBL95701 | — | Ki | = | 363.0 | nM | 6.44 |
| CHEMBL316520 | — | Ki | = | 553.0 | nM | 6.26 |
| CHEMBL316520 | — | Ki | > | 1000.0 | nM | - |