Assay Detail
Binding
CHEMBL809876
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for sigma receptor of guinea pig whole brain using [3H]-SKF- 100047 radioligand
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL287) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Piperidinyltetralin sigma ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 7.91 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL554874 | — | — | 1 | 9.00 |
| CHEMBL544123 | — | — | 1 | 8.72 |
| CHEMBL122165 | — | — | 1 | 8.70 |
| CHEMBL554437 | — | — | 1 | 8.70 |
| CHEMBL303336 | — | — | 1 | 8.62 |
| CHEMBL542709 | — | — | 1 | 8.52 |
| CHEMBL331470 | — | — | 1 | 8.40 |
| CHEMBL544594 | — | — | 1 | 8.40 |
| CHEMBL545285 | — | — | 1 | 8.40 |
| CHEMBL542942 | — | — | 1 | 8.36 |
| CHEMBL543889 | — | — | 1 | 8.30 |
| CHEMBL123014 | — | — | 1 | 8.15 |
| CHEMBL124234 | — | — | 1 | 8.10 |
| CHEMBL122538 | — | — | 1 | 8.05 |
| CHEMBL545058 | — | — | 1 | 8.05 |
| CHEMBL539288 | — | — | 1 | 8.00 |
| CHEMBL543412 | — | — | 1 | 8.00 |
| CHEMBL545287 | — | — | 1 | 7.96 |
| CHEMBL123937 | — | — | 1 | 7.96 |
| CHEMBL331172 | — | — | 1 | 7.89 |
| CHEMBL330865 | — | — | 1 | 7.89 |
| CHEMBL542462 | — | — | 1 | 7.82 |
| CHEMBL552572 | — | — | 1 | 7.72 |
| CHEMBL123488 | — | — | 1 | 7.62 |
| CHEMBL124411 | — | — | 1 | 7.58 |
| CHEMBL543176 | — | — | 1 | 7.58 |
| CHEMBL542217 | — | — | 1 | 7.58 |
| CHEMBL122761 | — | — | 1 | 7.46 |
| CHEMBL553311 | — | — | 1 | 7.34 |
| CHEMBL554873 | — | — | 1 | 7.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL554874 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL544123 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL122165 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL554437 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL303336 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL542709 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL331470 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL544594 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL545285 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL542942 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL543889 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL123014 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL124234 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL122538 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL545058 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL543412 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL539288 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL545287 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL123937 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL331172 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL330865 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL542462 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL552572 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL123488 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL124411 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL542217 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL543176 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL122761 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL553311 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL554873 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL122758 | — | Ki | = | 174.0 | nM | 6.76 |
| CHEMBL275707 | RIMCAZOLE | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL542946 | — | Ki | = | 1042.0 | nM | 5.98 |