Assay Detail
Binding
CHEMBL810015
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against porcine kidney amine oxidase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Amine oxidase [copper-containing] 3 (CHEMBL4592) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Combinatorial synthesis of SSAO inhibitors using sonogashira coupling: SAR of aryl propargylic amines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 4.79 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL945 | AMILORIDE | 4.0 | 1 | 5.00 |
| CHEMBL87563 | GABEXATE | 3.0 | 1 | 4.57 |
| CHEMBL134 | CLONIDINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL945 | AMILORIDE | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL87563 | GABEXATE | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL134 | CLONIDINE | Ki | = | 900000.0 | nM | - |