Assay Detail
Functional
CHEMBL810024
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LPS-stimulated TNF-alpha production in THP-1 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 9.20 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL328242 | — | — | 1 | 9.70 |
| CHEMBL419134 | — | — | 1 | 9.52 |
| CHEMBL419140 | — | — | 1 | 9.30 |
| CHEMBL316604 | — | — | 1 | 9.22 |
| CHEMBL96345 | — | — | 1 | 9.15 |
| CHEMBL327959 | — | — | 1 | 9.15 |
| CHEMBL327987 | — | — | 1 | 8.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL328242 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL419134 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL419140 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL316604 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL96345 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL327959 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL327987 | — | IC50 | = | 4.4 | nM | 8.36 |