Assay Detail
Functional
CHEMBL810907
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In vitro concentration required to kill 50% of T47D human breast ductal carcinoma cell line
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of a pro-drug of vinblastine targeted at treatment of prostate cancer with enhanced efficacy and reduced systemic toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.31 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL142678 | — | — | 1 | 6.82 |
| CHEMBL413081 | — | — | 1 | 5.80 |
| CHEMBL378544 | VINBLASTINE SULFATE | 4.0 | 1 | - |
| CHEMBL266634 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL142678 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL413081 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL378544 | VINBLASTINE SULFATE | EC50 | < | 80.0 | nM | - |
| CHEMBL266634 | — | EC50 | > | 50000.0 | nM | - |