Assay Detail
Functional
CHEMBL810909
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration on alkaline phosphatase activity in human T47D breast carcinoma cell line.
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel 6-aryl-1,4-dihydrobenzo[d]oxazine-2-thiones as potent, selective, and orally active nonsteroidal progesterone receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 48 | 8.18 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | 4.0 | 1 | 10.00 |
| CHEMBL25463 | — | — | 1 | 9.52 |
| CHEMBL280613 | — | — | 1 | 9.40 |
| CHEMBL282650 | — | — | 1 | 9.40 |
| CHEMBL282091 | — | — | 1 | 9.22 |
| CHEMBL25469 | — | — | 1 | 9.15 |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 9.05 |
| CHEMBL25462 | — | — | 1 | 9.05 |
| CHEMBL24621 | — | — | 1 | 9.00 |
| CHEMBL24965 | — | — | 1 | 8.96 |
| CHEMBL282649 | — | — | 1 | 8.92 |
| CHEMBL24245 | — | — | 1 | 8.90 |
| CHEMBL281182 | — | — | 1 | 8.82 |
| CHEMBL28199 | — | — | 1 | 8.82 |
| CHEMBL280956 | — | — | 1 | 8.77 |
| CHEMBL24380 | — | — | 1 | 8.77 |
| CHEMBL25017 | — | — | 1 | 8.60 |
| CHEMBL24922 | — | — | 1 | 8.60 |
| CHEMBL25015 | — | — | 1 | 8.60 |
| CHEMBL428513 | — | — | 1 | 8.59 |
| CHEMBL279464 | — | — | 1 | 8.33 |
| CHEMBL25415 | — | — | 1 | 8.24 |
| CHEMBL25556 | — | — | 1 | 8.24 |
| CHEMBL277422 | — | — | 1 | 8.14 |
| CHEMBL28255 | — | — | 1 | 8.14 |
| CHEMBL285872 | — | — | 1 | 7.94 |
| CHEMBL25181 | — | — | 1 | 7.94 |
| CHEMBL24581 | — | — | 1 | 7.58 |
| CHEMBL429056 | — | — | 1 | 7.38 |
| CHEMBL25036 | — | — | 1 | 7.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL25463 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL282650 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL280613 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL282091 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL25469 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL103 | PROGESTERONE | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL25462 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL24621 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL24965 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL282649 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL24245 | — | EC50 | = | 1.25 | nM | 8.90 |
| CHEMBL28199 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL281182 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL24380 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL280956 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL25017 | — | EC50 | = | 2.5 | nM | 8.60 |
| CHEMBL24922 | — | EC50 | = | 2.5 | nM | 8.60 |
| CHEMBL25015 | — | EC50 | = | 2.5 | nM | 8.60 |
| CHEMBL428513 | — | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL279464 | — | EC50 | = | 4.7 | nM | 8.33 |
| CHEMBL25415 | — | EC50 | = | 5.7 | nM | 8.24 |
| CHEMBL25556 | — | EC50 | = | 5.7 | nM | 8.24 |
| CHEMBL28255 | — | EC50 | = | 7.2 | nM | 8.14 |
| CHEMBL277422 | — | EC50 | = | 7.2 | nM | 8.14 |
| CHEMBL285872 | — | EC50 | = | 11.6 | nM | 7.94 |
| CHEMBL25181 | — | EC50 | = | 11.4 | nM | 7.94 |
| CHEMBL24581 | — | EC50 | = | 26.5 | nM | 7.58 |
| CHEMBL429056 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL25036 | — | EC50 | = | 44.9 | nM | 7.35 |
| CHEMBL24672 | — | EC50 | = | 49.8 | nM | 7.30 |
| CHEMBL25037 | — | EC50 | = | 79.5 | nM | 7.10 |
| CHEMBL24963 | — | EC50 | = | 80.1 | nM | 7.10 |
| CHEMBL280121 | — | EC50 | = | 88.5 | nM | 7.05 |
| CHEMBL25682 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL24913 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL283982 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL277644 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL25128 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL26763 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL417110 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL27922 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL24583 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL25454 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL26764 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL25292 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL28164 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL24689 | — | EC50 | > | 10000.0 | nM | - |