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Assay Detail

CHEMBL810918

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Binding
Inhibitory concentration against progesterone stimulated alkaline phosphatase activity in T47D human breast carcinoma cell line
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type T47D
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Progesterone receptor (CHEMBL208)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and progesterone receptor antagonist activities of 6-aryl benzimidazolones and benzothiazolones.
Zhang P, Terefenko EA, Wrobel J, Zhang Z, Zhu Y, Cohen J, Marschke KB, Mais D.
Bioorg Med Chem Lett (2001) 11 : 2747 -2750
PubMed 11591515 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 7.24 9.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1276308 MIFEPRISTONE 4.0 1 9.70
CHEMBL93906 1 8.00
CHEMBL316078 1 7.77
CHEMBL328332 1 7.54
CHEMBL93027 1 7.39
CHEMBL327409 1 7.21
CHEMBL327444 1 7.14
CHEMBL315445 1 7.08
CHEMBL329631 1 6.95
CHEMBL92026 1 6.95
CHEMBL94053 1 6.34
CHEMBL330271 1 6.00
CHEMBL92354 1 6.00
CHEMBL313850 1 -
CHEMBL273560 1 -
CHEMBL94162 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1276308 MIFEPRISTONE IC50 = 0.2 nM 9.70
CHEMBL93906 IC50 = 10.0 nM 8.00
CHEMBL316078 IC50 = 17.0 nM 7.77
CHEMBL328332 IC50 = 29.2 nM 7.54
CHEMBL93027 IC50 = 41.0 nM 7.39
CHEMBL327409 IC50 = 62.0 nM 7.21
CHEMBL327444 IC50 = 73.1 nM 7.14
CHEMBL315445 IC50 = 83.8 nM 7.08
CHEMBL329631 IC50 = 112.8 nM 6.95
CHEMBL92026 IC50 = 112.8 nM 6.95
CHEMBL94053 IC50 = 460.0 nM 6.34
CHEMBL330271 IC50 = 1000.0 nM 6.00
CHEMBL92354 IC50 = 1000.0 nM 6.00
CHEMBL313850 IC50 > 10000.0 nM -
CHEMBL273560 IC50 > 10000.0 nM -
CHEMBL94162 IC50 > 10000.0 nM -