Assay Detail
Binding
CHEMBL811340
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for sigma-1 receptor measured on guinea pig brain membranes using [3H](+)-pentazocine as radioligand.
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL287) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and structure-activity relationships of naphthamides as dopamine D3 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 34 | 7.89 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54027 | — | — | 1 | 9.15 |
| CHEMBL53078 | — | — | 1 | 8.96 |
| CHEMBL51856 | — | — | 1 | 8.96 |
| CHEMBL54026 | — | — | 1 | 8.92 |
| CHEMBL54092 | — | — | 1 | 8.92 |
| CHEMBL53320 | — | — | 1 | 8.77 |
| CHEMBL53401 | — | — | 1 | 8.72 |
| CHEMBL54571 | — | — | 1 | 8.60 |
| CHEMBL50465 | — | — | 1 | 8.49 |
| CHEMBL53778 | — | — | 1 | 8.44 |
| CHEMBL298759 | — | — | 1 | 8.40 |
| CHEMBL54667 | — | — | 1 | 8.32 |
| CHEMBL54865 | — | — | 1 | 8.24 |
| CHEMBL298875 | — | — | 1 | 8.23 |
| CHEMBL301302 | — | — | 1 | 8.21 |
| CHEMBL51754 | — | — | 1 | 8.21 |
| CHEMBL301732 | — | — | 1 | 7.90 |
| CHEMBL54662 | — | — | 1 | 7.78 |
| CHEMBL53038 | — | — | 1 | 7.68 |
| CHEMBL53218 | — | — | 1 | 7.63 |
| CHEMBL52298 | — | — | 1 | 7.55 |
| CHEMBL416481 | — | — | 1 | 7.51 |
| CHEMBL50517 | — | — | 1 | 7.32 |
| CHEMBL53650 | — | — | 1 | 7.25 |
| CHEMBL52835 | — | — | 1 | 7.24 |
| CHEMBL52300 | — | — | 1 | 7.23 |
| CHEMBL423122 | — | — | 1 | 7.16 |
| CHEMBL52588 | — | — | 1 | 7.13 |
| CHEMBL298864 | — | — | 1 | 7.02 |
| CHEMBL50352 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54027 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL53078 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL51856 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL54026 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL54092 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL53320 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL53401 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL54571 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL50465 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL53778 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL298759 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL54667 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL54865 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL298875 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL51754 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL301302 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL301732 | — | Ki | = | 12.7 | nM | 7.90 |
| CHEMBL54662 | — | Ki | = | 16.7 | nM | 7.78 |
| CHEMBL53038 | — | Ki | = | 20.7 | nM | 7.68 |
| CHEMBL53218 | — | Ki | = | 23.4 | nM | 7.63 |
| CHEMBL52298 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL416481 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL50517 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL53650 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL52835 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL52300 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL423122 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL52588 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL298864 | — | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL50352 | — | Ki | = | 121.0 | nM | 6.92 |
| CHEMBL53102 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL301929 | — | Ki | = | 375.0 | nM | 6.43 |
| CHEMBL416846 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL54866 | — | Ki | > | 1000.0 | nM | - |