Assay Detail
Binding
CHEMBL811638
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Activity against TXA2 synthase in bovine platelet microsome
12
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Dibenzoxepin derivatives: thromboxane A2 synthase inhibition and thromboxane A2 receptor antagonism combined in one molecule.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.80 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26820 | (E)-ISBOGREL | — | 1 | 8.54 |
| CHEMBL40736 | — | — | 3 | 8.40 |
| CHEMBL11811 | ONO-1581 | — | 1 | 8.37 |
| CHEMBL40937 | — | — | 1 | 7.85 |
| CHEMBL296746 | — | — | 1 | 7.27 |
| CHEMBL116869 | — | — | 1 | 6.35 |
| CHEMBL296720 | — | — | 1 | 5.85 |
| CHEMBL289076 | — | — | 1 | 5.72 |
| CHEMBL288420 | — | — | 1 | 4.77 |
| CHEMBL8273 | SULOTROBAN | 2.0 | 1 | 4.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26820 | (E)-ISBOGREL | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL40736 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL11811 | ONO-1581 | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL40736 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL40937 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL296746 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL40736 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL116869 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL296720 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL289076 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL288420 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL8273 | SULOTROBAN | IC50 | = | 94100.0 | nM | 4.03 |