Compound Detail
CHEMBL11811
ONO-1581 Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL11811 |
| Name | ONO-1581 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZAPOSLLMEZKFQS-NBYYMMLRSA-M |
| Parent Compound | CHEMBL27829 |
| Active Moiety | CHEMBL27829 |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
253.3
MW (Da)
3.16
ALogP
2
HBA
1
HBD
50.2
PSA (Ų)
0.85
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.37
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Thromboxane-A synthase CHEMBL1835 | IC50 | 8.37 | 6.945 | 4.3 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Thromboxane-A synthase | IC50 | = | 4.3 | nM | 8.37 | Activity against TXA2 synthase in bovine platelet microsome | 8496929 |
| Thromboxane-A synthase | IC50 | = | 3000.0 | nM | 5.52 | Inhibitory activity against Thromboxane A2 synthase in human platelet microsome | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 3735314 | 10.1021/jm00158a024 | Thromboxane-A synthase | 5 |
| 8496929 | 10.1021/jm00063a011 | Unchecked | 1 |
| 8496929 | 10.1021/jm00063a011 | Thromboxane-A synthase | 1 |
| - | 10.1016/0960-894X(95)00171-O | Homo sapiens | 1 |
| - | 10.1016/0960-894X(95)00171-O | Thromboxane-A synthase | 1 |
| 8230108 | 10.1021/jm00073a023 | Thromboxane-A synthase | 1 |
Data from ChEMBL 36 via Core Engine