Assay Detail
Binding
CHEMBL812555
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effect of compound on Serotonin transporter uptake from rat cortex using [3H]citalopram as radioligand
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Novel, potent, and selective 5-HT3 receptor antagonists based on the arylpiperazine skeleton: synthesis, structure, biological activity, and comparative molecular field analysis studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.91 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL276520 | INDALPINE | 4.0 | 1 | 8.70 |
| CHEMBL18772 | QUIPAZINE | 2.0 | 1 | 7.37 |
| CHEMBL59871 | — | — | 1 | 6.48 |
| CHEMBL64879 | — | — | 1 | 6.44 |
| CHEMBL62636 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL276520 | INDALPINE | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL18772 | QUIPAZINE | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL59871 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL64879 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL62636 | — | Ki | = | 2600.0 | nM | 5.58 |