Assay Detail

CHEMBL813541

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Functional

In vitro guinea pig tracheal relaxation

ChEMBL ↗

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Target

Cavia porcellus (CHEMBL369) ↗

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Cavia porcellus (CHEMBL369) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Cavia porcellus

CHEMBL369

Anchored from Assay target.

Protein identity Cavia porcellus

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Cavia porcellus
Tissue	Trachea
Confidence	1 — Organism
Curated By	Expert

Target

Cavia porcellus (CHEMBL369) ↗

Type	ORGANISM
Organism	Cavia porcellus

Publication

Selective inhibitors of cyclic AMP-specific phosphodiesterase: heterocycle-condensed purines.

Sawanishi H, Suzuki H, Yamamoto S, Waki Y, Kasugai S, Ohya K, Suzuki N, Miyamoto K, Takagi K.
J Med Chem (1997) 40 : 3248 -3253
PubMed 9379444 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	5.74	6.92

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL18701	RO-201724	—	1	6.92
CHEMBL1355736	THEOPHYLLINE	4.0	1	4.55

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL18701	RO-201724	EC50	=	120.0	nM	6.92
CHEMBL1355736	THEOPHYLLINE	EC50	=	28000.0	nM	4.55