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Assay Detail

CHEMBL813630

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Binding
Tested for the Inhibition of the catalytic activity of human Thrombin at 25 degree C and pH 7.5.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Prothrombin (CHEMBL204)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

DERIVATIVES OF 4-AMINO-PYRIDINE AS SELECTIVE THROMBIN INHIBITORS
von der Saal W, Kucznierz R, Leinert H, Engh RA
Bioorg Med Chem Lett (1997) 7 : 1283 -1288
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 16 6.05 8.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL51173 1 8.22
CHEMBL282549 1 7.16
CHEMBL25835 1 6.70
CHEMBL23813 1 6.52
CHEMBL23252 1 6.16
CHEMBL24827 1 5.82
CHEMBL23468 1 5.70
CHEMBL25890 1 5.55
CHEMBL23246 1 5.16
CHEMBL281715 1 5.00
CHEMBL23243 1 4.52
CHEMBL284348 DALFAMPRIDINE 4.0 1 -
CHEMBL24479 1 -
CHEMBL285311 1 -
CHEMBL23300 1 -
CHEMBL20936 BENZAMIDINE 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL51173 Ki = 6.0 nM 8.22
CHEMBL282549 Ki = 70.0 nM 7.16
CHEMBL25835 Ki = 200.0 nM 6.70
CHEMBL23813 Ki = 300.0 nM 6.52
CHEMBL23252 Ki = 700.0 nM 6.16
CHEMBL24827 Ki = 1500.0 nM 5.82
CHEMBL23468 Ki = 2000.0 nM 5.70
CHEMBL25890 Ki = 2800.0 nM 5.55
CHEMBL23246 Ki = 7000.0 nM 5.16
CHEMBL281715 Ki = 10000.0 nM 5.00
CHEMBL23243 Ki = 30000.0 nM 4.52
CHEMBL284348 DALFAMPRIDINE Ki > 2000000.0 nM -
CHEMBL24479 Ki > 500000.0 nM -
CHEMBL285311 Ki = 120000.0 nM -
CHEMBL23300 Ki = 300000.0 nM -
CHEMBL20936 BENZAMIDINE Ki = 220000.0 nM -