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Assay Detail

CHEMBL813636

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
The compound was evaluated for inhibitory activity against Thrombin
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Prothrombin (CHEMBL204)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Bisbenzamidine isoxazoline derivatives as factor Xa inhibitors
Quan M, Pruitt J, Ellis C, Liauw A, Galemmo R, Stouten P, Wityak J, Knabb R, Thoolen M, Wong P, Wexler R
Bioorg Med Chem Lett (1997) 7 : 2813 -2818
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 10 5.12 5.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL94799 1 5.66
CHEMBL317590 1 5.66
CHEMBL96879 1 5.51
CHEMBL97842 1 4.96
CHEMBL94563 1 4.95
CHEMBL93445 1 4.93
CHEMBL94761 1 4.85
CHEMBL92988 1 4.80
CHEMBL93657 1 4.80
CHEMBL433351 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL94799 Ki = 2200.0 nM 5.66
CHEMBL317590 Ki = 2200.0 nM 5.66
CHEMBL96879 Ki = 3100.0 nM 5.51
CHEMBL97842 Ki = 11100.0 nM 4.96
CHEMBL94563 Ki = 11200.0 nM 4.95
CHEMBL93445 Ki = 11800.0 nM 4.93
CHEMBL94761 Ki = 14100.0 nM 4.85
CHEMBL92988 Ki = 16000.0 nM 4.80
CHEMBL93657 Ki = 16000.0 nM 4.80
CHEMBL433351 Ki > 21000.0 nM -