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Assay Detail

CHEMBL813667

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro for inhibition of thrombin.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Prothrombin (CHEMBL204)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

(N-acyl-N-alkyl)glycyl borolysine analogs: A new class of potent thrombin inhibitors
Galemmo RA, Fevig JM, Carini DJ, Cacciola J, Wells BL, Hillyer GL, Buriak J, Rossi KA, Stouten PF, Alexander RS, Hilmer R, Bostrom L, Abelman MM, Lee S, Weber PC, Kettner CA, Knabb RM, Wexler RR
Bioorg Med Chem Lett (1996) 6 : 2913 -2918
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 16 8.76 10.39

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL290376 1 10.39
CHEMBL95940 1 9.80
CHEMBL100109 1 9.62
CHEMBL99309 1 9.38
CHEMBL317137 1 9.16
CHEMBL320897 1 9.10
CHEMBL101759 1 8.85
CHEMBL330206 1 8.80
CHEMBL317682 1 8.77
CHEMBL431814 1 8.68
CHEMBL101707 1 8.33
CHEMBL419892 1 8.31
CHEMBL330149 1 8.27
CHEMBL95993 1 8.04
CHEMBL100187 1 7.80
CHEMBL317587 1 6.91

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL290376 Ki = 0.041 nM 10.39
CHEMBL95940 Ki = 0.16 nM 9.80
CHEMBL100109 Ki = 0.24 nM 9.62
CHEMBL99309 Ki = 0.42 nM 9.38
CHEMBL317137 Ki = 0.69 nM 9.16
CHEMBL320897 Ki = 0.8 nM 9.10
CHEMBL101759 Ki = 1.4 nM 8.85
CHEMBL330206 Ki = 1.6 nM 8.80
CHEMBL317682 Ki = 1.71 nM 8.77
CHEMBL431814 Ki = 2.1 nM 8.68
CHEMBL101707 Ki = 4.68 nM 8.33
CHEMBL419892 Ki = 4.9 nM 8.31
CHEMBL330149 Ki = 5.4 nM 8.27
CHEMBL95993 Ki = 9.1 nM 8.04
CHEMBL100187 Ki = 16.0 nM 7.80
CHEMBL317587 Ki = 123.0 nM 6.91