Compound Detail
CHEMBL95993
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Basic Information
| ChEMBL ID | CHEMBL95993 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BNQKKJULGXDFIQ-HNNXBMFYSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
362.2
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 4 meas. best 8.04
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Prothrombin CHEMBL204 | Ki | 8.04 | 8.04 | 9.1 | 1 |
| Serine protease 1 CHEMBL209 | Ki | 7.68 | 7.68 | 21.0 | 1 |
| Prothrombin CHEMBL4471 | Ki | 6.4 | 6.4 | 400.0 | 1 |
| Tissue-type plasminogen activator CHEMBL1873 | Ki | 5.16 | 5.16 | 7000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Prothrombin | Ki | = | 9.1 | nM | 8.04 | In vitro for inhibition of thrombin. | - |
| Serine protease 1 | Ki | = | 21.0 | nM | 7.68 | Compound was tested in vitro for inhibition of trypsin | - |
| Prothrombin | Ki | = | 400.0 | nM | 6.4 | Concentration necessary to double time for clot formation induced by bovine thro... | - |
| Tissue-type plasminogen activator | Ki | = | 7000.0 | nM | 5.16 | Compound was tested in vitro for inhibition of tissue plasminogen activator | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(96)00525-2 | Prothrombin | 2 |
| - | 10.1016/S0960-894X(96)00525-2 | Unchecked | 2 |
| - | 10.1016/S0960-894X(96)00525-2 | Serine protease 1 | 1 |
| - | 10.1016/S0960-894X(96)00525-2 | Thrombin & trypsin | 1 |
| - | 10.1016/S0960-894X(96)00525-2 | Plasminogen | 1 |
| - | 10.1016/S0960-894X(96)00525-2 | Tissue-type plasminogen activator | 1 |
Data from ChEMBL 36 via Core Engine