Assay Detail
Functional
CHEMBL814525
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration in vitro against the bloodstream trypomastigote form of Trypanosoma brucei
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.30 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 7.70 |
| CHEMBL423172 | MEGAZOL | — | 1 | 7.40 |
| CHEMBL140232 | — | — | 1 | 6.70 |
| CHEMBL136514 | — | — | 1 | 6.30 |
| CHEMBL139243 | — | — | 1 | 5.10 |
| CHEMBL344833 | — | — | 1 | 4.60 |
| CHEMBL138246 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL265502 | SURAMIN | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL423172 | MEGAZOL | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL140232 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL136514 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL139243 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL344833 | — | EC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL138246 | — | EC50 | > | 41000.0 | nM | - |