Assay Detail
Functional
CHEMBL814693
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Inhibition of [3H]spermidine transport by the compound was evaluated in T-47D human breast cancer cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of spermidine and norspermidine dimers as high affinity polyamine transport inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 5.41 | 6.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23194 | SPERMINE | 0.5 | 1 | 6.04 |
| CHEMBL47324 | — | — | 1 | 5.82 |
| CHEMBL49799 | — | — | 1 | 5.75 |
| CHEMBL45514 | — | — | 1 | 5.70 |
| CHEMBL423846 | — | — | 1 | 5.70 |
| CHEMBL47876 | — | — | 1 | 5.62 |
| CHEMBL19612 | SPERMIDINE | 3.0 | 1 | 5.36 |
| CHEMBL47066 | — | — | 1 | 5.31 |
| CHEMBL1160143 | — | — | 1 | 4.90 |
| CHEMBL300482 | — | — | 1 | 4.77 |
| CHEMBL47947 | — | — | 1 | 4.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23194 | SPERMINE | Ki | = | 920.0 | nM | 6.04 |
| CHEMBL47324 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL49799 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL45514 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL423846 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL47876 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL19612 | SPERMIDINE | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL47066 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL1160143 | — | Ki | = | 12600.0 | nM | 4.90 |
| CHEMBL300482 | — | Ki | = | 16900.0 | nM | 4.77 |
| CHEMBL47947 | — | Ki | = | 25600.0 | nM | 4.59 |