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Assay Detail

CHEMBL814778

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Functional
Antitrypanosomal activity against Trypanosoma cruzi epimastigotes
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma cruzi
Confidence 1 — Organism
Curated By Expert

Target

Trypanosoma cruzi (CHEMBL368)
Type ORGANISM
Organism Trypanosoma cruzi

Publication

New synthesis of benzo-delta-carbolines, cryptolepines, and their salts: in vitro cytotoxic, antiplasmodial, and antitrypanosomal activities of delta-carbolines, benzo-delta-carbolines, and cryptolepines.
Arzel E, Rocca P, Grellier P, Labaeïd M, Frappier F, Guéritte F, Gaspard C, Marsais F, Godard A, Quéguiner G.
J Med Chem (2001) 44 : 949 -960
PubMed 11300877 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 30 5.30 6.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL368186 1 6.64
CHEMBL176533 1 6.52
CHEMBL369051 1 6.47
CHEMBL424964 1 6.27
CHEMBL172918 1 6.14
CHEMBL172017 1 5.89
CHEMBL366607 1 5.64
CHEMBL172479 1 5.55
CHEMBL369675 1 5.50
CHEMBL173684 1 5.41
CHEMBL176893 1 5.20
CHEMBL176545 1 5.18
CHEMBL171841 1 5.17
CHEMBL224248 QUINDOLINE 1 5.06
CHEMBL368103 1 4.98
CHEMBL174748 1 4.96
CHEMBL366482 1 4.95
CHEMBL424954 1 4.73
CHEMBL368594 1 4.67
CHEMBL175276 1 4.63
CHEMBL174540 1 4.58
CHEMBL368642 1 4.46
CHEMBL368165 1 4.30
CHEMBL367105 1 4.23
CHEMBL176519 1 -
CHEMBL367738 1 -
CHEMBL367658 1 -
CHEMBL369038 1 -
CHEMBL369473 1 -
CHEMBL175417 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL368186 IC50 = 230.0 nM 6.64
CHEMBL176533 IC50 = 300.0 nM 6.52
CHEMBL369051 IC50 = 340.0 nM 6.47
CHEMBL424964 IC50 = 540.0 nM 6.27
CHEMBL172918 IC50 = 730.0 nM 6.14
CHEMBL172017 IC50 = 1300.0 nM 5.89
CHEMBL366607 IC50 = 2300.0 nM 5.64
CHEMBL172479 IC50 = 2800.0 nM 5.55
CHEMBL369675 IC50 = 3200.0 nM 5.50
CHEMBL173684 IC50 = 3900.0 nM 5.41
CHEMBL176893 IC50 = 6300.0 nM 5.20
CHEMBL176545 IC50 = 6600.0 nM 5.18
CHEMBL171841 IC50 = 6800.0 nM 5.17
CHEMBL224248 QUINDOLINE IC50 = 8700.0 nM 5.06
CHEMBL368103 IC50 = 10400.0 nM 4.98
CHEMBL174748 IC50 = 11100.0 nM 4.96
CHEMBL366482 IC50 = 11200.0 nM 4.95
CHEMBL424954 IC50 = 18600.0 nM 4.73
CHEMBL368594 IC50 = 21400.0 nM 4.67
CHEMBL175276 IC50 = 23200.0 nM 4.63
CHEMBL174540 IC50 = 26400.0 nM 4.58
CHEMBL368642 IC50 = 34400.0 nM 4.46
CHEMBL368165 IC50 = 49800.0 nM 4.30
CHEMBL367105 IC50 = 58400.0 nM 4.23
CHEMBL176519 IC50 = 129000.0 nM -
CHEMBL367738 IC50 > 550000.0 nM -
CHEMBL367658 IC50 = 428000.0 nM -
CHEMBL369038 IC50 > 200000.0 nM -
CHEMBL369473 IC50 > 300000.0 nM -
CHEMBL175417 IC50 > 312000.0 nM -