Assay Detail
Functional
CHEMBL814911
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Tested in vitro for trypanocidal activity against a drug sensitive strain of Trypanosoma brucei Lab 110 EATRO
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Polyamines with N-(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.17 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL86281 | — | — | 1 | 6.92 |
| CHEMBL82641 | — | — | 1 | 6.66 |
| CHEMBL85189 | — | — | 1 | 6.57 |
| CHEMBL85198 | — | — | 1 | 6.51 |
| CHEMBL84221 | — | — | 1 | 6.40 |
| CHEMBL62048 | — | — | 1 | 6.18 |
| CHEMBL86096 | — | — | 1 | 6.09 |
| CHEMBL85161 | — | — | 1 | 5.52 |
| CHEMBL310207 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL86281 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL82641 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL85189 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL85198 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL84221 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL62048 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL86096 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL85161 | — | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL310207 | — | IC50 | = | 22000.0 | nM | 4.66 |